DNA Vaccines - 6 Angebote vergleichen
Bester Preis: € 106,42 (vom 15.04.2017)1
DNA Vaccines
EN NWISBN: 9781461349259 bzw. 1461349257, in Englisch, Springer-Verlag New York Inc. neu.
Lieferung aus: Vereinigtes Königreich Großbritannien und Nordirland, in-stock.
Antigens encoded by DNA vaccines can induce all arms of the adaptive immune response, but to date they have proven most effective at inducing antigen-specific CD8+ T cells. The great majority of experiments have been carried out in small animal models, where these vac- cines work quite well; in a limited number of studies in primates (including humans), their effectiveness, although demonstrable, is somewhat diminished. Therefore, to accelerate the introduction of DNA vaccines into clinical and veterinary practice, it is important that their immunogenicity be enhanced. The rational modification of DNA vaccines requires that we have a basic understanding of the mechanisms which underpin successful DNA immuniza- tion. In this chapter, we review how DNA vaccines may work, and how this information per- mits us to exploit biological pathways to improve the outcome of genetic immunization. In addition to reviewing "rational" vaccine modification (based on, e.g. , targeting antigens to specific antigen presentation pathways; or co-administering cytokines to modulate the vaccine-induced response) we also consider "empirical" approaches, such as using different prime-boost regimens which-by a mechanism as yet unclear-appear to greatly enhance antigen-specific memory in the vaccinee. Empirical studies proved the efficacy of essentially all vaccines in current use, and this old approach may once again prove useful in launching a new technology into the clinical arena. References 1. Whitton JL. Lymphocytic choriomeningitis virus CTL. Sem Virol 1990; 1:257-262. 2. Good RA. and Zak SJ. Disturbance in gamma-globulin synthesis as "experiments of nature".
Antigens encoded by DNA vaccines can induce all arms of the adaptive immune response, but to date they have proven most effective at inducing antigen-specific CD8+ T cells. The great majority of experiments have been carried out in small animal models, where these vac- cines work quite well; in a limited number of studies in primates (including humans), their effectiveness, although demonstrable, is somewhat diminished. Therefore, to accelerate the introduction of DNA vaccines into clinical and veterinary practice, it is important that their immunogenicity be enhanced. The rational modification of DNA vaccines requires that we have a basic understanding of the mechanisms which underpin successful DNA immuniza- tion. In this chapter, we review how DNA vaccines may work, and how this information per- mits us to exploit biological pathways to improve the outcome of genetic immunization. In addition to reviewing "rational" vaccine modification (based on, e.g. , targeting antigens to specific antigen presentation pathways; or co-administering cytokines to modulate the vaccine-induced response) we also consider "empirical" approaches, such as using different prime-boost regimens which-by a mechanism as yet unclear-appear to greatly enhance antigen-specific memory in the vaccinee. Empirical studies proved the efficacy of essentially all vaccines in current use, and this old approach may once again prove useful in launching a new technology into the clinical arena. References 1. Whitton JL. Lymphocytic choriomeningitis virus CTL. Sem Virol 1990; 1:257-262. 2. Good RA. and Zak SJ. Disturbance in gamma-globulin synthesis as "experiments of nature".
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Rabies and Rabies Vaccines
~EN HC NWISBN: 9783030210830 bzw. 3030210839, vermutlich in Englisch, Springer Shop, gebundenes Buch, neu.
Lieferung aus: Österreich, Lagernd, zzgl. Versandkosten.
This book reviews the recent advances in rabies research and rabies vaccine development. The reader is introduced to biology and pathology of the virus, causing agents and the history of rabies vaccination. The book presents regional rabies prophylaxis programs and discusses vaccination strategies for wildlife and humans. Further, innate immune response as well as antibody response to rabies are examined. All chapters are written by renowned experts in rabies research, some of them part of the WHO Collaboration Centre for Rabies Surveillance and Research. The book targets researchers and health professionals working in Virology, Veterinary Medicine and Biomedicine. Hard cover.
This book reviews the recent advances in rabies research and rabies vaccine development. The reader is introduced to biology and pathology of the virus, causing agents and the history of rabies vaccination. The book presents regional rabies prophylaxis programs and discusses vaccination strategies for wildlife and humans. Further, innate immune response as well as antibody response to rabies are examined. All chapters are written by renowned experts in rabies research, some of them part of the WHO Collaboration Centre for Rabies Surveillance and Research. The book targets researchers and health professionals working in Virology, Veterinary Medicine and Biomedicine. Hard cover.
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Rabies and Rabies Vaccines
~EN HC NWISBN: 9783030210830 bzw. 3030210839, vermutlich in Englisch, Springer International Publishing, gebundenes Buch, neu.
Lieferung aus: Vereinigte Staaten von Amerika, Lagernd, zzgl. Versandkosten.
Rabies-and-Rabies-Vaccines~~Hildegund-C-J-Ertl, Rabies and Rabies Vaccines, Hardcover.
Rabies-and-Rabies-Vaccines~~Hildegund-C-J-Ertl, Rabies and Rabies Vaccines, Hardcover.
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