Designing of Oral Sustained Release Bioadhesive Drug Delivery System
3 Angebote vergleichen
Bester Preis: € 87,90 (vom 02.05.2019)1
Designing of Oral Sustained Release Bioadhesive Drug Delivery System
~EN NWISBN: 9783659712913 bzw. 3659712914, vermutlich in Englisch, neu.
Lieferung aus: Vereinigtes Königreich Großbritannien und Nordirland, Lieferzeit: 11 Tage.
The objective of the present study was to develop "once daily" sustained-release bioadhesive tablet of Zaltoprofen (ZLT) and Lornoxicam (LXM) which will deliver the drug it in small doses over an extended period and localizing it in the intestine by bioadhesion. ZLT is a new non-steroidal anti-inflammatory drug which has anti-inflammatory, analgesic and antipyretic effect and frequently used for rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, acute gout. ZLT has short biological half-life (4.96 - 7.48h) and blood drug level decrease in short time so that patients need frequent administration (t.i.d). The sustained-release polymers, hydroxypropyl methylcellulose (HPMC) of different viscosities and xanthan gum evaluated in different proportions as a major matrix material. Drug-polymer compatibility studies by FTIR and DSC gave confirmation about their purity and showed no interaction physically between drug and selected polymers. ZLT matrix tablets were prepared by wet granulation. The effect of polymer concentration on the drug release profile and in-vitro bioadhesion of the matrix tablets was studied.
The objective of the present study was to develop "once daily" sustained-release bioadhesive tablet of Zaltoprofen (ZLT) and Lornoxicam (LXM) which will deliver the drug it in small doses over an extended period and localizing it in the intestine by bioadhesion. ZLT is a new non-steroidal anti-inflammatory drug which has anti-inflammatory, analgesic and antipyretic effect and frequently used for rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, acute gout. ZLT has short biological half-life (4.96 - 7.48h) and blood drug level decrease in short time so that patients need frequent administration (t.i.d). The sustained-release polymers, hydroxypropyl methylcellulose (HPMC) of different viscosities and xanthan gum evaluated in different proportions as a major matrix material. Drug-polymer compatibility studies by FTIR and DSC gave confirmation about their purity and showed no interaction physically between drug and selected polymers. ZLT matrix tablets were prepared by wet granulation. The effect of polymer concentration on the drug release profile and in-vitro bioadhesion of the matrix tablets was studied.
2
Designing of Oral Sustained Release Bioadhesive Drug Delivery System - for NSAID's
~EN PB NWISBN: 9783659712913 bzw. 3659712914, vermutlich in Englisch, LAP Lambert Academic Publishing, Taschenbuch, neu.
Lieferung aus: Deutschland, Versandkostenfrei.
Designing of Oral Sustained Release Bioadhesive Drug Delivery System: The objective of the present study was to develop `once daily` sustained-release bioadhesive tablet of Zaltoprofen (ZLT) and Lornoxicam (LXM) which will deliver the drug it in small doses over an extended period and localizing it in the intestine by bioadhesion. ZLT is a new non-steroidal anti-inflammatory drug which has anti-inflammatory, analgesic and antipyretic effect and frequently used for rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, acute gout. ZLT has short biological half-life (4.96 - 7.48h) and blood drug level decrease in short time so that patients need frequent administration (t.i.d). The sustained-release polymers, hydroxypropyl methylcellulose (HPMC) of different viscosities and xanthan gum evaluated in different proportions as a major matrix material. Drug-polymer compatibility studies by FTIR and DSC gave confirmation about their purity and showed no interaction physically between drug and selected polymers. ZLT matrix tablets were prepared by wet granulation. The effect of polymer concentration on the drug release profile and in-vitro bioadhesion of the matrix tablets was studied. Englisch, Taschenbuch.
Designing of Oral Sustained Release Bioadhesive Drug Delivery System: The objective of the present study was to develop `once daily` sustained-release bioadhesive tablet of Zaltoprofen (ZLT) and Lornoxicam (LXM) which will deliver the drug it in small doses over an extended period and localizing it in the intestine by bioadhesion. ZLT is a new non-steroidal anti-inflammatory drug which has anti-inflammatory, analgesic and antipyretic effect and frequently used for rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, acute gout. ZLT has short biological half-life (4.96 - 7.48h) and blood drug level decrease in short time so that patients need frequent administration (t.i.d). The sustained-release polymers, hydroxypropyl methylcellulose (HPMC) of different viscosities and xanthan gum evaluated in different proportions as a major matrix material. Drug-polymer compatibility studies by FTIR and DSC gave confirmation about their purity and showed no interaction physically between drug and selected polymers. ZLT matrix tablets were prepared by wet granulation. The effect of polymer concentration on the drug release profile and in-vitro bioadhesion of the matrix tablets was studied. Englisch, Taschenbuch.
Lade…