Role of Notch Pathway in the Pathogenesis of T- All (Paperback)
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Von Händler/Antiquariat, BuySomeBooks [52360437], Las Vegas, NV, U.S.A.
This item is printed on demand. Paperback. As was shown in the literature over the years Notch pathway was reported to play an essential role in the pathogenesis of T-ALL. However, most studies concentrated on the role of Notch1 owing to the discovery of several mutations which are present in 50 of T-ALL cases. On the other hand a controversy was reported regarding the role of Notch3 in T-ALL where some authors reported its pivotal role in T-ALL while others dismissed its role due to the absence of mutations in this gene. Thus in this work our aim was to study the expression of the main genes involved in the Notch pathway namely Notch1, Notch3, Hes1 and the gene encoding pT alpha, to verify the role of Notch1 versus Notch3 in the pathogenesis of T-ALL and to correlate the level of the expression of such genes to other prognostic parameters. We also wanted to compare children to adults as ALL constitutes two different pathological entities in the two age groups This item ships from La Vergne,TN.

Lieferung aus: Deutschland, Versandkostenfrei.
Von Händler/Antiquariat, The Book Depository EURO [60485773], Gloucester, UK, United Kingdom.
Language: English Brand New Book ***** Print on Demand *****.As was shown in the literature over the years Notch pathway was reported to play an essential role in the pathogenesis of T-ALL. However, most studies concentrated on the role of Notch1 owing to the discovery of several mutations which are present in > 50 of T-ALL cases. On the other hand a controversy was reported regarding the role of Notch3 in T-ALL where some authors reported its pivotal role in T-ALL while others dismissed its role due to the absence of mutations in this gene. Thus in this work our aim was to study the expression of the main genes involved in the Notch pathway namely Notch1, Notch3, Hes1 and the gene encoding pT alpha, to verify the role of Notch1 versus Notch3 in the pathogenesis of T-ALL and to correlate the level of the expression of such genes to other prognostic parameters. We also wanted to compare children to adults as ALL constitutes two different pathological entities in the two age groups.

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As was shown in the literature over the years Notch pathway was reported to play an essential role in the pathogenesis of T-ALL. However, most studies concentrated on the role of Notch1 owing to the discovery of several mutations which are present in 50% of T-ALL cases. On the other hand a controversy was reported regarding the role of Notch3 in T-ALL where some authors reported its pivotal role in T-ALL while others dismissed its role due to the absence of mutations in this gene. Thus in this work our aim was to study the expression of the main genes involved in the Notch pathway namely Notch1, Notch3, Hes1 and the gene encoding pT alpha, to verify the role of Notch1 versus Notch3 in the pathogenesis of T-ALL and to correlate the level of the expression of such genes to other prognostic parameters. We also wanted to compare children to adults as ALL constitutes two different pathological entities in the two age groups.

Lieferung aus: Deutschland, Versandkostenfrei.
Role of Notch Pathway in the pathogenesis of T- ALL: As was shown in the literature over the years Notch pathway was reported to play an essential role in the pathogenesis of T-ALL. However, most studies concentrated on the role of Notch1 owing to the discovery of several mutations which are present in 50% of T-ALL cases. On the other hand a controversy was reported regarding the role of Notch3 in T-ALL where some authors reported its pivotal role in T-ALL while others dismissed its role due to the absence of mutations in this gene. Thus in this work our aim was to study the expression of the main genes involved in the Notch pathway namely Notch1, Notch3, Hes1 and the gene encoding pT alpha, to verify the role of Notch1 versus Notch3 in the pathogenesis of T-ALL and to correlate the level of the expression of such genes to other prognostic parameters. We also wanted to compare children to adults as ALL constitutes two different pathological entities in the two age groups, Englisch, Taschenbuch.

Von Händler/Antiquariat, Paperbackshop-US [8408184], Secaucus, NJ, U.S.A.
New Book. This item is printed on demand. Shipped from US This item is printed on demand.

Von Händler/Antiquariat, English-Book-Service - A Fine Choice [1048135], Waldshut-Tiengen, Germany.
This item is printed on demand for shipment within 3 working days.

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