Intracellular ion channel 1 between neurogenesis and neurodegeneration S: Intracellular ion channel 1 between neurogenesi
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Intracellular ion channel 1 between neurogenesis and neurodegeneration: CLIC1 in neuronal physiology and pathology (2014)
EN PB US
ISBN: 9783639718980 bzw. 3639718984, in Englisch, 132 Seiten, Scholars' Press, Taschenbuch, gebraucht.
Ново от: $65.98 (11 Оферти)
Използван от: $103.40 (2 Оферти)
Покажи още 13 Оферти в Amazon.com
Lieferung aus: Vereinigte Staaten von Amerika, Usually ships in 1-2 business days.
Von Händler/Antiquariat, super_star_seller.
The “cell cycle hypothesis” for neurodegenerative diseases suggests a link between "cell cycle-like reactivation" and neuronal death, mainly in Alzheimer disease (AD), one of the most common neurodegenerative diseases for which an efficient treatment is yet to be identified. The “insult” represented by Aβ deposits, a typical hallmark of AD, could force the neuron to re-enter the cell cycle. However, a highly differentiated cell unable to successfully accomplish a task normally attributable to immature cells, would end up in neuronal death. Considering neurodegeneration as a result of the abnormal activation in mature cells of a pathway that is typical of immature cells, the results shown in this book propose CLIC1 as part of this pathway, physiological and “successful” in immature cells, contributing to mantain growth cone morphology and sustaining axon outgrowth modulated by cAMP via PKA, but leading to cell death in “mature” neurons. Increased CLIC1 expression in the gangliar layer in AD mouse models before cognitive symptoms, proposes it as an early marker of AD. This study suggests a double role of CLIC1, in retinal ganglion cells physiology and pathology. Paperback, Етикет: Scholars' Press, Scholars' Press, Продуктова група: Book, Публикувани: 2014-07-01, Дата на издаване: 2014-07-01, Студио: Scholars' Press.
Von Händler/Antiquariat, super_star_seller.
The “cell cycle hypothesis” for neurodegenerative diseases suggests a link between "cell cycle-like reactivation" and neuronal death, mainly in Alzheimer disease (AD), one of the most common neurodegenerative diseases for which an efficient treatment is yet to be identified. The “insult” represented by Aβ deposits, a typical hallmark of AD, could force the neuron to re-enter the cell cycle. However, a highly differentiated cell unable to successfully accomplish a task normally attributable to immature cells, would end up in neuronal death. Considering neurodegeneration as a result of the abnormal activation in mature cells of a pathway that is typical of immature cells, the results shown in this book propose CLIC1 as part of this pathway, physiological and “successful” in immature cells, contributing to mantain growth cone morphology and sustaining axon outgrowth modulated by cAMP via PKA, but leading to cell death in “mature” neurons. Increased CLIC1 expression in the gangliar layer in AD mouse models before cognitive symptoms, proposes it as an early marker of AD. This study suggests a double role of CLIC1, in retinal ganglion cells physiology and pathology. Paperback, Етикет: Scholars' Press, Scholars' Press, Продуктова група: Book, Публикувани: 2014-07-01, Дата на издаване: 2014-07-01, Студио: Scholars' Press.
2
Intracellular Ion Channel 1 Between Neurogenesis and Neurodegeneration
EN NW
ISBN: 9783639718980 bzw. 3639718984, in Englisch, Scholars' Press, neu.
Lieferung aus: Vereinigtes Königreich Großbritannien und Nordirland, zzgl. Versandkosten, in-stock.
The "cell cycle hypothesis" for neurodegenerative diseases suggests a link between "cell cycle-like reactivation" and neuronal death, mainly in Alzheimer disease (AD), one of the most common neurodegenerative diseases for which an efficient treatment is yet to be identified. The "insult" represented by AB deposits, a typical hallmark of AD, could force the neuron to re-enter the cell cycle. However, a highly differentiated cell unable to successfully accomplish a task normally attributable to immature cells, would end up in neuronal death. Considering neurodegeneration as a result of the abnormal activation in mature cells of a pathway that is typical of immature cells, the results shown in this book propose CLIC1 as part of this pathway, physiological and "successful" in immature cells, contributing to mantain growth cone morphology and sustaining axon outgrowth modulated by cAMP via PKA, but leading to cell death in "mature" neurons. Increased CLIC1 expression in the gangliar layer in AD mouse models before cognitive symptoms, proposes it as an early marker of AD. This study suggests a double role of CLIC1, in retinal ganglion cells physiology and pathology.
The "cell cycle hypothesis" for neurodegenerative diseases suggests a link between "cell cycle-like reactivation" and neuronal death, mainly in Alzheimer disease (AD), one of the most common neurodegenerative diseases for which an efficient treatment is yet to be identified. The "insult" represented by AB deposits, a typical hallmark of AD, could force the neuron to re-enter the cell cycle. However, a highly differentiated cell unable to successfully accomplish a task normally attributable to immature cells, would end up in neuronal death. Considering neurodegeneration as a result of the abnormal activation in mature cells of a pathway that is typical of immature cells, the results shown in this book propose CLIC1 as part of this pathway, physiological and "successful" in immature cells, contributing to mantain growth cone morphology and sustaining axon outgrowth modulated by cAMP via PKA, but leading to cell death in "mature" neurons. Increased CLIC1 expression in the gangliar layer in AD mouse models before cognitive symptoms, proposes it as an early marker of AD. This study suggests a double role of CLIC1, in retinal ganglion cells physiology and pathology.
3
Intracellular Ion Channel 1 Between Neurogenesis and Neurodegeneration (2014)
DE PB NW
ISBN: 9783639718980 bzw. 3639718984, in Deutsch, Scholars Press, Taschenbuch, neu.
Lieferung aus: Niederlande, 5-10 werkdagen.
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Intracellular Ion Channel 1 Between Neurogenesis and Neurodegeneration
DE PB NW
ISBN: 9783639718980 bzw. 3639718984, in Deutsch, Scholars' Press, Taschenbuch, neu.
Lieferung aus: Vereinigtes Königreich Großbritannien und Nordirland, zzgl. Versandkosten, Verandgebiet: EUR.
Von Händler/Antiquariat, Paperbackshop International, GLOS, Fairford, [RE:4].
Softcover.
Von Händler/Antiquariat, Paperbackshop International, GLOS, Fairford, [RE:4].
Softcover.
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