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Tetramer Stability And Functional Regulation Of Tumor Suppressor Protein P53
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Bester Preis: € 88,60 (vom 11.04.2017)Tetramer Stability and Functional Regulation of Tumor Suppressor Protein P53
ISBN: 9784431541349 bzw. 4431541349, Sprache unbekannt, Springer Verlag, Japan, neu.
This thesis presents the first report of the comprehensive and quantitative analysis of the effects of tumor-derived mutations on the tetrameric structure of tumor suppressor protein p53, which plays a central role in maintaining genomic integrity. Inactivation of p53 via mutation of its gene is a key step in tumorigenesis. Biophysical analyses revealed that the stability of the mutant peptides varied widely. Formation of a tetrameric structure is to be critical for protein protein interactions, DNA binding, and the post-translational modification of p53. A small destabilization of the tetrameric structure therefore could result in dysfunction of tumor suppressor activity. This work suggests that the threshold for loss of tumor suppressor activity, in terms of the disruption of p53 s tetrameric structure, could be extremely low. Furthermore, functional control of p53 via tetramer formation was demonstrated, based on the structure function analysis of mutant p53. The results disclosed that relatively small changes in tetramer formation, induced by the stabilization or inhibition of homo-tetramerization, could control p53 function.
Tetramer Stability and Functional Regulation of Tumor Suppressor Protein p53 (2012)
ISBN: 9784431541356 bzw. 4431541357, Sprache unbekannt, Springer, Springer, Springer, neu, E-Book, elektronischer Download.
This thesis presents the first report of the comprehensive and quantitative analysis of the effects of tumor-derived mutations on the tetrameric structure of tumor suppressor protein p53, which plays a central role in maintaining genomic integrity. Inactivation of p53 via mutation of its gene is a key step in tumorigenesis. Biophysical analyses revealed that the stability of the mutant peptides varied widely. Formation of a tetrameric structure is to be critical for protein-protein interactions, DNA binding, and the post-translational modification of p53. A small destabilization of the tetrameric structure therefore could result in dysfunction of tumor suppressor activity. This work suggests that the threshold for loss of tumor suppressor activity, in terms of the disruption of p53's tetrameric structure, could be extremely low. Furthermore, functional control of p53 via tetramer formation was demonstrated, based on the structure-function analysis of mutant p53. The results disclosed that relatively small changes in tetramer formation, induced by the stabilization or inhibition of homo-tetramerization, could control p53 function.
Tetramer Stability and Functional Regulation of Tumor Suppressor Protein p53
ISBN: 9784431541349 bzw. 4431541349, Sprache unbekannt, Springer Japan, neu.
Rui Kamada, Books, Science and Nature, Tetramer Stability and Functional Regulation of Tumor Suppressor Protein p53, This thesis presents the first report of the comprehensive and quantitative analysis of the effects of tumor-derived mutations on the tetrameric structure of tumor suppressor protein p53, which plays a central role in maintaining genomic integrity. Inactivation of p53 via mutation of its gene is a key step in tumorigenesis. Biophysical analyses revealed that the stability of the mutant peptides varied widely. Formation of a tetrameric structure is to be critical for protein-protein interactions, DNA binding, and the post-translational modification of p53. A small destabilization of the tetrameric structure therefore could result in dysfunction of tumor suppressor activity. This work suggests that the threshold for loss of tumor suppressor activity, in terms of the disruption of p53's tetrameric structure, could be extremely low. Furthermore, functional control of p53 via tetramer formation was demonstrated, based on the structure-function analysis of mutant p53. The results disclosed that relatively small changes in tetramer formation, induced by the stabilization or inhibition of homo-tetramerization, could control p53 function.
Tetramer Stability And Functional Regulation Of Tumor Suppressor Protein P53
ISBN: 9784431547259 bzw. 4431547258, Sprache unbekannt, Springer Japan, neu.
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Tetramer Stability and Functional Regulation of Tumor Suppressor Protein p53
ISBN: 9784431547259 bzw. 4431547258, Sprache unbekannt, Springer Japan, Taschenbuch, neu.
Die Beschreibung dieses Angebotes ist von geringer Qualität oder in einer Fremdsprache. Trotzdem anzeigen
Tetramer Stability and Functional Regulation of Tumor Suppressor Protein p53
ISBN: 9784431541349 bzw. 4431541349, Sprache unbekannt, Springer Japan, gebundenes Buch, neu.
Die Beschreibung dieses Angebotes ist von geringer Qualität oder in einer Fremdsprache. Trotzdem anzeigen
Tetramer Stability and Functional Regulation of Tumor Suppressor Protein p53 (2012)
ISBN: 4431541349 bzw. 9784431541349, Sprache unbekannt, Springer-Verlag GmbH; Springer Tokyo, neu.
Die Beschreibung dieses Angebotes ist von geringer Qualität oder in einer Fremdsprache. Trotzdem anzeigen