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Pradeep Das (?):

Structure Identification Inhibitors Designing Against Hgprtase (?)

ISBN: 9783659303906 (?) bzw. 3659303909, in Deutsch, LAP LAMBERT Academic Publishing, Taschenbuch, neu

93,47 + Versand: 4,23 = 97,70(unverbindlich)
Von Händler/Antiquariat, BuySomeBooks [52360437], Las Vegas, NV, U.S.A.
Paperback. 108 pages. Dimensions: 8.7in. x 5.9in. x 0.2in.The present study focuses on HGPRT target inhibitors search based on proteins of purine salvage pathway in Leishmania donovani. For this we had modelled HGPRT protein using comparative modelling and their validated, based on which docking (DS2. 0 and GOLD program) calculations were done. In the next step, active sites were explored to allow compounds to dock. Finally, we screened common hits amongst these protein inhibitors and GMP analogous as wel as reported Leishmanial inhibitors. Top compounds were validated and their QSAR and ADMETox profiles were also predicted by using TSAR in Discovery studio. Some ligands(acyclovir and pentamidine) have shown good dock score and fitness score in the protein target. Interaction profiles can be further utilized to build computational novel structures. The further work needed to validate the hits molecules in assays and optimize the lead molecules This item ships from multiple locations. Your book may arrive from Roseburg,OR, La Vergne,TN.
Paperback. 108 pages. Dimensions: 8.7in. x 5.9in. x 0.2in.The present study focuses on HGPRT target inhibitors search based on proteins of purine salvage pathway in Leishmania donovani. For this we had modelled HGPRT protein using comparative modelling and their validated, based on which docking (DS2. 0 and GOLD program) calculations were done. In the next step, active sites were explored to allow compounds to dock. Finally, we screened common hits amongst these protein inhibitors and GMP analogous as wel as reported Leishmanial inhibitors. Top compounds were validated and their QSAR and ADMETox profiles were also predicted by using TSAR in Discovery studio. Some ligands(acyclovir and pentamidine) have shown good dock score and fitness score in the protein target. Interaction profiles can be further utilized to build computational novel structures. The further work needed to validate the hits molecules in assays and optimize the lead molecules This item ships from multiple locations. Your book may arrive from Roseburg,OR, La Vergne,TN.
Kommentar des Händlers/Antiquariats BuySomeBooks [52360437], Las Vegas, NV, U.S.A.:
Händlerbewertung: 5, NEW BOOK, New
Bestellnummer bei der Plattform Abebooks.de: 10797812190
Schlüsselwörter: PRADEEP DAS,MD YOUSUF ANSARI,GANESH CHANDRA SAHOO,BIOLOGY
Daten vom 16.04.2015 23:50h
ISBN (andere Schreibweisen): 3-659-30390-9, 978-3-659-30390-6
Ansari MD Yousuf; Sahoo Ganesh Chandra and Das Pradeep:
Structure identification Inhibitors designing against HGPRTase: By Insilico, SAR ADME/Tox prediction
Zuerst gefunden: 17.01.2013 08:18:05
Zuletzt gefunden: 16.04.2015 23:50:03
Kleinster Preis: 43,70 (vom 17.09.2013 17:39:27)
Höchster Preis: 104,67 (vom 16.04.2015 23:50:03)
Fundstellen insgesamt: 23
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