Regulators and Effectors of Small GTPases: Ras Family (Methods in Enzymology)
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Regulators and Effectors of Small GTPases: Ras Family
EN NW
ISBN: 9780080463599 bzw. 0080463592, Band: 406, in Englisch, Elsevier Science, neu.
Lieferung aus: Deutschland, مفت شپنگ.
Regulators and Effectors of Small GTPases: Ras Family: The Ras superfamily (>150 human members) encompasses Ras GTPases involved in cell proliferation, Rho GTPases involved in regulating the cytoskeleton, Rab GTPases involved in membrane targeting/fusion and a group of GTPases including Sar1, Arf, Arl and dynamin involved in vesicle budding/fission. These GTPases act as molecular switches and their activities are controlled by a large number of regulatory molecules that affect either GTP loading (guanine nucleotide exchange factors or GEFs) or GTP hydrolysis (GTPase activating proteins or GAPs). In their active state, they interact with a continually increasing, functionally complex array of downstream effectors. Since the last Methods in Enzymology volume on this topic in 2000, the study of Ras Family GTPases has witnessed a plethora of new directions and trends. With regards to the founding member of the Ras superfamily, the study of Ras in oncogenesis has seen the development and application of more advanced model cell culture and animal systems. The discovery of mutationally activated B-Raf in human cancers has injected renewed interest in this classical effector pathway of Ras.Includes a database for Ras family proteins and their effectors and regulators Complimentary to volume 406 coverage of the Rho family Over 150 international contributors, Englisch, Ebook.
Regulators and Effectors of Small GTPases: Ras Family: The Ras superfamily (>150 human members) encompasses Ras GTPases involved in cell proliferation, Rho GTPases involved in regulating the cytoskeleton, Rab GTPases involved in membrane targeting/fusion and a group of GTPases including Sar1, Arf, Arl and dynamin involved in vesicle budding/fission. These GTPases act as molecular switches and their activities are controlled by a large number of regulatory molecules that affect either GTP loading (guanine nucleotide exchange factors or GEFs) or GTP hydrolysis (GTPase activating proteins or GAPs). In their active state, they interact with a continually increasing, functionally complex array of downstream effectors. Since the last Methods in Enzymology volume on this topic in 2000, the study of Ras Family GTPases has witnessed a plethora of new directions and trends. With regards to the founding member of the Ras superfamily, the study of Ras in oncogenesis has seen the development and application of more advanced model cell culture and animal systems. The discovery of mutationally activated B-Raf in human cancers has injected renewed interest in this classical effector pathway of Ras.Includes a database for Ras family proteins and their effectors and regulators Complimentary to volume 406 coverage of the Rho family Over 150 international contributors, Englisch, Ebook.
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Regulators and Effectors of Small GTPases: Ras Family (Methods in Enzymology) (2006)
EN NW FE EB DL
ISBN: 9780080463599 bzw. 0080463592, Band: 406, in Englisch, 780 Seiten, Academic Press, neu, Erstausgabe, E-Book, elektronischer Download.
Lieferung aus: Vereinigtes Königreich Großbritannien und Nordirland, ڈاؤن لوڈ، اتارنا کے لئے ای بُک, مفت شپنگ ہے ۔.
The Ras superfamily (>150 human members) encompasses Ras GTPases involved in cell proliferation, Rho GTPases involved in regulating the cytoskeleton, Rab GTPases involved in membrane targeting/fusion and a group of GTPases including Sar1, Arf, Arl and dynamin involved in vesicle budding/fission. These GTPases act as molecular switches and their activities are controlled by a large number of regulatory molecules that affect either GTP loading (guanine nucleotide exchange factors or GEFs) or GTP hydrolysis (GTPase activating proteins or GAPs). In their active state, they interact with a continually increasing, functionally complex array of downstream effectors. Since the last Methods in Enzymology volume on this topic in 2000, the study of Ras Family GTPases has witnessed a plethora of new directions and trends. With regards to the founding member of the Ras superfamily, the study of Ras in oncogenesis has seen the development and application of more advanced model cell culture and animal systems. The discovery of mutationally activated B-Raf in human cancers has injected renewed interest in this classical effector pathway of Ras.Includes a database for Ras family proteins and their effectors and regulators Complimentary to volume 406 coverage of the Rho family Over 150 international contributors, Kindle Edition, ایڈیشن: 1, وضع: Kindle eBook, لیبل: Academic Press, Academic Press, مصنوعات گروپ: eBooks, شائع: 2006-06-07, تاریخ کی رہائی: 2006-06-07, سٹوڈیو: Academic Press, سیلز کے عہدے: 2365648.
The Ras superfamily (>150 human members) encompasses Ras GTPases involved in cell proliferation, Rho GTPases involved in regulating the cytoskeleton, Rab GTPases involved in membrane targeting/fusion and a group of GTPases including Sar1, Arf, Arl and dynamin involved in vesicle budding/fission. These GTPases act as molecular switches and their activities are controlled by a large number of regulatory molecules that affect either GTP loading (guanine nucleotide exchange factors or GEFs) or GTP hydrolysis (GTPase activating proteins or GAPs). In their active state, they interact with a continually increasing, functionally complex array of downstream effectors. Since the last Methods in Enzymology volume on this topic in 2000, the study of Ras Family GTPases has witnessed a plethora of new directions and trends. With regards to the founding member of the Ras superfamily, the study of Ras in oncogenesis has seen the development and application of more advanced model cell culture and animal systems. The discovery of mutationally activated B-Raf in human cancers has injected renewed interest in this classical effector pathway of Ras.Includes a database for Ras family proteins and their effectors and regulators Complimentary to volume 406 coverage of the Rho family Over 150 international contributors, Kindle Edition, ایڈیشن: 1, وضع: Kindle eBook, لیبل: Academic Press, Academic Press, مصنوعات گروپ: eBooks, شائع: 2006-06-07, تاریخ کی رہائی: 2006-06-07, سٹوڈیو: Academic Press, سیلز کے عہدے: 2365648.
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